Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep773 | Clinical case reports - Thyroid/Others | ECE2017

Nivolumab-associated pituitary, adrenal and thyroid autoimmune disorders

Bettencourt-Silva Rita , Oliveira Joana , Esteves Cesar , Hespanhol Venceslau , Fernandes Gabriela , Caeiro Claudia , Queiros Joana , Carvalho Davide

Background: Nivolumab is a monoclonal antibody specific for human PD-1 (programmed cell death protein-1), a checkpoint molecule highly expressed in several cancers. Nivolumab is an immunotherapeutic strategy for human cancer, but it can interfere with endocrine system.Case reports: We report four cases regarding nivolumab-associated endocrinopathies: (i) Male, 55-year-old, with previous normal cortisol and adrenocorticotropic hormone (ACTH) levels, treat...